Independent Research Projects

Dragonfly Research conducts independent research projects. These studies are investigator initiated and done nearly entirely “in-house”. The research projects are presented annually at the Consortium of Multiple Sclerosis Centers Annual Meeting.


ACAPELLA: Real-World Experience with Ocrelizumab, Year Two Data

We sought to examine the frequency of AEs in a real-world population receiving OCR with characteristics outside the inclusion parameters of the phase II & III trials, focusing on infections requiring antibiotics and neoplasms. This dataset reflects results two years after FDA approval of OCR.


ACAPELLA: Hypogammaglobulinemia and JCV Status in Ocrelizumab-Treated Patients

As part of the ACAPELLA trial (a prospective study assessing OCR-associated adverse events in a real-world population, see poster DXT63), we evaluated the impact of OCR on immunoglobulin levels and JCV titers over time as well as any correlation between IgG levels and infection risk. In patients with low IgG, we evaluated immune function through measurement of specific antibody titers. This dataset reflects results collected through March 15, 2019.


Psoriasis Exacerbation during Ocrelizumab Therapy for Relapsing Multiple Sclerosis: A Case Report

The objective is to describe a case of preexisting psoriasis with acute disseminated psoriasis following treatment with Ocrevus.

Poster acapella 2018.JPG

ACAPELLA: Real World Experience with Ocrelizumab: An Observational Study Evaluating Safety in Patients with Relapsing and Progressive Multiple Sclerosis

We sought to compare the frequency of adverse events (AEs) in our population of patients on Ocrevus with the clinical trial population (CTP), and to determine if AEs were more frequent in subjects with age and/or EDSS outside the inclusion criteria of the Phase III trials. This data set reflects results at one year.


PML and IRIS: Between a Rock and a Hard Place

The objective of the study was to describe the clinical course, radiologic findings, treatment, and outcomes of 6 patients with natalizumab-associated PML and IRIS treated at The Elliot Lewis Center from 2012 to 2016.

Poster WOE.JPG

Characterizing the Natalizumab “Wearing Off” Effect

The objective of the study was to characterize the prevalence and clinical features of the natalizumab Wearing Off Effect in our patient population.


To Pee or Not To Pee? The Utility of Bladder Scans in Multiple Sclerosis

The objective of the project was to evaluate the frequency of asymptomatic urinary retention and UTIs to assess the utility of PVR measurement in the office setting and to examine the correlation of urinary symptoms with the presence of spinal cord lesions.

Poster tys interview.JPG

Understanding Concepts Important to Natalizumab Patients: A Qualitative Interview Study

The objective of the project was to understand concepts that are the most meaningful to MS patients treated with natalizumab and how patients weigh the benefits/risks of treatment.